Rhinovirus-induced interferon production is not deficient in well controlled asthma

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Rhinovirus-induced interferon production is not deficient in well controlled asthma.

BACKGROUND Defective rhinovirus (RV)-induced interferon (IFN)-β and IFN-λ production and increased RV replication have been reported in primary human bronchial epithelial cells (HBECs) from subjects with asthma. How universal this defect is in asthma is unknown. Additionally, the IFN subtypes induced by RV infection in primary HBECs have not been comprehensively investigated. OBJECTIVE To stu...

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Rhinovirus-induced interferon production in asthma.

After reading the article by Sykes et al, we would like to comment on impaired response to rhinovirus in relation to asthma severity. The authors examined rhinovirus-induced interferon (IFN) production in a cohort of asthmatic patients compared with controls. While they previously reported in this population a reduced IFN production in cells from bronchoalveolar lavage, they fail to document su...

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Identifying 'well-controlled' and 'not well-controlled' asthma using the Asthma Control Questionnaire.

The 7-item Asthma Control Questionnaire (ACQ) has been validated to measure the goals of asthma management as defined by international guidelines (minimisation of day- and night-time symptoms, activity limitation, beta(2)-agonist use and bronchoconstriction). Responses are given on a 7-point scale and the overall score is the mean of the responses (0=totally controlled, 6=severely uncontrolled)...

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Rhinovirus-Induced Exacerbations of Asthma and COPD

Over the past two decades, increasing evidence has shown that, in patients with chronic airways disease, viral infection is the most common cause of exacerbation. This review will examine the evidence for viral-induced exacerbations of asthma and chronic obstructive lung disease and the potential mechanisms by which viruses cause exacerbations. Attention will be focused on rhinovirus, the most ...

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Effect of induced interferon in experimental rhinovirus infections in volunteers.

Nasal administration of an interferon inducer, CP-20,961 (N, N-dioctadecyl-N', N'-bis(2-hydroxyethyl)propanediamine), was evaluated in a double-blind, placebo-controlled study of experimental rhinovirus infection in 29 volunteers. Detectable nasal interferon developed in 10 of 15 subjects treated with CP-20,961, and 2 of 14 in the group receiving placebo (P < 0.006). Titers of CP-20,961-induced...

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ژورنال

عنوان ژورنال: Thorax

سال: 2013

ISSN: 0040-6376,1468-3296

DOI: 10.1136/thoraxjnl-2012-202909